Four Great Axioms / Syllogisms of Madhyamaka. 1) The vajra fragments {rdo rje zegs ma}; 2) the production and cessation of the four limits {mu bzhi skye 'gog}; 3) the supreme relativity {rten 'brel chen po}; 4) and the singular and the multiple {gcig dang du bral}. See also {gtan tshigs lnga}.