佛在世時毘耶離城有五種之惡病流行：一自眼出血，二自耳出膿，三自鼻流血，四舌噤無聲，五所食之物變為麤澀。見請觀音經，輔行二之二。
Five epidemics in Vaiśālī during the Buddha's lifetime-- bleeding from the eyes, pus from the ears, nose-bleeding, lockjaw, and astringent taste of all food.
一五種惡病 佛住世時，毘舍離國所流行之五種大惡病。即：(1)兩眼赤如血，(2)兩耳出膿，(3)鼻中流血，(4)舌噤無聲，(5)所食之物變為粗澀。〔請觀音經、止觀輔行傳弘決卷二之二〕p1554